SO FATIGUED... anyone experienced this??  My INR has been very unstable for past two years.  Been on coumadin permanently since '91 (stroke) (Initial DVT in 1960).  I have Lupus plus Antiphospholipid Antibody Syndrome APS, Sjogrens Syndrome, and every hypercoagulable disorder possible.  I think about 50% of SLE pts. get these blood clotting disorders as part of their Lupus.  As patients age, the body no longer "wants" coumadin and doses get lower and lower and harder to manage.  My INR has jumped all over from 9.3 last month to 2.8 and other radical readings for 2+ years.  Part is from recent antibiotics (pneumonia) and super-high boost of Prednisone (Evil-Drug).  Does anyone have experience with getting extremely fatigued, as in EXHAUSTED, when their INR is radiical?????  I'm certain that it is what makes me "wiped out" and barely able to function at times, but with so many meds (esp. the daily Prednisone 10mg now) how can I tell.  After years, you'd think I would know more, but I don't cuz it gets crazier.  Please share what do you FEEL and reactions and symptoms when your INR is jumping around.  I would really appreciate this.  Since I don't know which is the best place to post this, I may also put it at the Discussion Board also.  ALL INFORMATION would be greatly appreciated. Basically, what side effects do you have or notice when your INR is too high or too low.  (Mine is managed at higher-then-normal with target 3-5.)